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BOSTON & CAMBRIDGE, Mass.–(BUSINESS WIRE)–Ginkgo Bioworks, the animal company, and Synlogic, Inc. (Nasdaq: SYBX), the clinical-stage biologic analysis and development aggregation developing atypical Constructed Biotic™ medicines, today appear a accord to ascertain new active medicines to amusement acoustic and alarmist disorders. Constructed Biotic medicines are active medicines in which engineered probiotics are advised to accomplish analytical metabolic conversions in the gut that can alter physiological action missing or damaged in patients.

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Together, Synlogic and Ginkgo aim to transform the analysis and architecture of active medicines. Ginkgo’s automatic branch and adeptness in high-throughput animal screening and design, accumulated with Synlogic’s insights and adeptness in discovery, translational and analytic development of Constructed Biotic medicines will enhance Synlogic’s able biologic analysis engine, enabling abundance through bags of biologic leads with abundant acceleration and precision. Synlogic’s amount adeptness in architecture Constructed Biotic medicines for clinically-relevant potency, quantitative pharmacology, dosage response, and reproducible accomplishment will added advance the development of atypical gut-based therapeutics.

“Combining constructed analysis and the microbiome to accomplish active medicines is a novel, able access to developing treatments for a avant-garde array of conditions,” said Jason Kelly, CEO of Ginkgo Bioworks. “We accept activated our automatic branch to architecture bacilli for a avant-garde ambit of industries and are aflame to advantage our belvedere for analysis development for the actual aboriginal time. Synlogic is the absolute accomplice for us as we set out to accompany the claiming of designing active medicines.”

This accord is the aboriginal footfall against an advancing ample accomplishment to accomplish a portfolio of transformational active anesthetic biologic leads. The focus of this accord will be accumulation access capabilities, establishing the alive archetypal abaft the collective analysis engine, and breeding biologic leads. The parties apprehend to added coact to analyze how their technologies can be acclimated to amusement a ample ambit of acoustic and alarmist conditions. The companies will accordingly seek cardinal ally for portfolio expansion, analytic development, and commercialization in these ache areas.

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“Our mission is to alleviate the ample abeyant of Constructed Biotic medicines and accompany them to patients,” said JC Gutiérrez-Ramos, Ph.D., Synlogic’s admiral and CEO. “There is massive charge amid the about 100 actor Americans adversity from acoustic altitude and 30 actor from alarmist disease. There is able accurate affirmation that neurologic altitude can be articulate by demography advantage of the accustomed cantankerous allocution amid gut and the brain, a chat that involves hundreds of well-characterized metabolites. In our first-in-human abstraction to amusement hyperammonemia, we approved a pharmacological aftereffect and dosage responses on systemic metabolites with a Constructed Biotic anesthetic that acts from the gut. As we empiric this aftereffect in non-human primates in our phenylketonuria program, we now accept two examples in baneful encephalopathies of Constructed Biotic medicines modifying metabolites through their programmed mechanisms while acting in altered regions of the gut in animal and non-human primates. We attending avant-garde to creating a able new biologic analysis and development agent with Ginkgo to bear Constructed Biotic medicines to attune metabolites that access the academician and liver.”

There is abeyant for both parties to added advance technology generated during the collaboration. Banking agreement of the accord are not disclosed.

About Ginkgo Bioworks

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Headquartered in Boston, Ginkgo Bioworks uses the best avant-garde technology on the planet – analysis – to abound articles instead of accomplishment them. The company’s technology belvedere is bringing biotechnology into customer appurtenances markets, enabling fragrance, cosmetic, nutrition, food, agronomics and pharmaceuticals to accomplish bigger products. For added information, visit www.ginkgobioworks.com.

About Synlogic

Synlogic is beat the development of a atypical chic of living, Constructed Biotic medicines, based on its proprietary biologic development platform. Synlogic’s antecedent activity includes Constructed Biotic medicines for the analysis of attenuate abiogenetic diseases, such as urea aeon disorders (UCD) and phenylketonuria (PKU). In addition, the aggregation is leveraging the ample abeyant of its belvedere to actualize Constructed Biotic medicines for the analysis of added accepted diseases, including alarmist disease, anarchic and allowed disorders, and cancer. Synlogic is accommodating with AbbVie to advance Constructed Biotic-based treatments for anarchic bowel ache (IBD). For added information, amuse visit www.synlogictx.com.

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Forward-Looking Statements

This columnist absolution contains “forward-looking statements” that absorb abundant risks and uncertainties for purposes of the safe anchorage provided by the Private Securities Litigation Reform Act of 1995. All statements, added than statements of actual facts, included in this columnist absolution apropos strategy, approaching operations, approaching banking position, approaching revenue, projected expenses, prospects, affairs and objectives of administration are advanced statements. In addition, back or if acclimated in this columnist release, the words “may,” “could,” “should,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “predict” and agnate expressions and their variants, as they chronicle to Synlogic may analyze advanced statements. Examples of advanced statements, include, but are not bound to, statements apropos the abeyant of Synlogic’s and Ginkgo’s platforms to advance analysis to abode a avant-garde ambit of diseases, including acoustic and alarmist disorders; the approaching analytic development of Constructed Biotic medicines; the access that Synlogic and Gingko are demography to ascertain and advance atypical analysis application constructed biology; the abeyant of Synlogic’s technology to amusement hyperammonemia. Actual after-effects could alter materially from those independent in any advanced account as a aftereffect of assorted factors, including: the uncertainties inherent in the preclinical development process; the adeptness of Synlogic to assure its bookish acreage rights; and legislative, regulatory, political and bread-and-butter developments, as able-bodied as those risks articular beneath the branch “Risk Factors” in Synlogic’s filings with the SEC. The advanced statements independent in this columnist absolution reflect Synlogic’s accepted angle with account to approaching events. Synlogic anticipates that consecutive contest and developments will account its angle to change. However, while Synlogic may accept to amend these advanced statements in the future, Synlogic accurately disclaims any obligation to do so. These advanced statements should not be relied aloft as apery Synlogic’s appearance as of any date consecutive to the date hereof.

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